genetherapy相关论文
Lentiviral vectors (LVs),derived from human immunodeficiency virus,are powerful tools for modifying the genes of eukaryo......
Therapeutic potential of glial cell line-derived neurotrophic factor and cell reprogramming for hipp
Hippocampus serves as a pivotal role in cognitive and emotional processes, as well as in the regulation of the hypothala......
Rescue of male infertility through correcting a genetic mutation causing meiotic arrest in spermatog
Azoospermia patients who carry a monogenetic mutation that causes meiotic arrest may have their biological child through......
Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord inju
Despite emerging contemporary biotechnological methods such as gene- and stemcell-based therapy, there are no clinically......
Among various cancer gene therapy approaches, suicide gene therapy seems to be an effective system characteristic with t......
To be able to label a gene and monitor its migration are key important approaches for the clinical application of cancer......
Light and redox dual sensitive supramolecular self-assembly system based on branched polycations for
Gene therapy has provided great potential to cure a series of diseases,like cancers and diabetes.However,cationic polyme......
Cationic polymers are widely used as nonvirial vectors to compact negatively charged DNA into DNA/polymer complexes (pol......
Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into
RNA interference (RNAi) has been considered as a promising strategy for the effective treatment of cancer.However,the ea......
In the past few years,gene therapy has been investigated as an innovative therapeutic technique for treatment of various......
Dendrimers have become prominent synthetic macromolecules for drug delivery thanks to their unique properties of high dr......
Development of a Novel Folic Acid Chitosan Supported Imidazole Schiff Base for Tumor Targeted Gene D
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Gene therapy has played great roles in many disease treatments including cancer therapy.However,inefficient intracellula......
Direct in vivo administration of messenger RNA (mRNA) delivered in both naked and nanoparticle formats are actively inve......
Gene therapy is a promising approach to treat various human genetic and acquired diseases.Extensive efforts have been ex......
Gene therapy as a promising therapeutic approach for cancer treatment has drawn great attention for the past decades[1].......
We investigated the repair effect of co-expression of the hVEGF and hBMP genes via an adeno-associated viral (AAV) vecto......
Disc Gene Therapy:Development of a novel inducible system toregulate expression of the therapeutic t
Purpose: We successfully developed a new gene therapy recombinant adeno-associated viral(rAAV)vector,rAAV-NF?BhTIMP1....
Gene Transfer of Connective Tissue Growth Factor and Tissue Inhibitor of Metalloproteinases 1 Increa
Objectives To assess the co-effects of human CTGF and TIMP-1 on the proteoglycan synthesis of degenerated human interver......
Delivery of RIPK4 small interfering RNA for bladder cancer therapy using natural halloysite nanotube
Objective Gene therapy has been receiving increasing attention in tumour eradication,especially when encompassing target......
Localized RNA Interference Therapy to Eliminate Residual Lung Cancer after Incomplete Microwave Abla
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Photo-responsive hollow silica nanoparticles for light triggered gene and photodynamic synergistic t
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Feasibility and effect of ultrasound microbubblemediatedwild-type p53 gene transfection of HeLa cell
Objective Gene therapy holds great promise for the treatment of diseases.The key problem of gene therapy is the choice o......
The chemotherapy of glioma is usually failure due to the multidrug resistance.The authors investigated the reversal effe......
Up-regulated expression of NT-3 mediated by hypoxia response element attenuates cerebral ischemia/re
To investigate the neuroprotective effects of neurotrophin-3(NT-3) expression controlled by five copies of the hypoxia-r......
Objective: Establish VEGF-gene-modified artificial bone , and explore its ability to repaire bone defects.Methods: Use m......
BACKGROUND Gene therapy may be a promising approach for the treatment of Leber hereditary optic neuropathy.The aim of th......
Hypoxia-regulated neurotrophin-3 expression mediated by multicopy hypoxia response elements and redu
We have previously reported that five copies of the hypoxia response element (HRE) can conditionally regulate brain-deri......
Cerebral infarction is a common and frequently encountered disease,which is mostly onset in people after middle age.For ......
Intrathecal injection:an effective technique to implement gene transfection inside central nerve sys
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Intracellular calcium concentration of corpus cavernosum smooth muscle cells is decreased by the ove
To investigate the effects of adipose tissuederived stem cells (ADSCs) modified with penile neuronal nitric oxide syntha......
Adeno-associated virus (AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parki......
Expression of an Intrabody against Human Cyclin D1 Provides Antitumor Efficacy on Hepatocellular Car
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A key barrier to the development of gene therapy remains the lack of safe, efficient and easily controllable vehicles fo......
Synergistic enhancement of hepatocellular carcinoma therapy using a combination of anti-miR-181b and
MicroRNAs (miRNAs) play an essential role in inhibiting hepatocellular carcinoma (HCC) via several different pathways.Ho......
Nerve Growth Factor-modified Mesenchymal Stem Cells Enhance Recovery of Inferior Alveolar Nerve in R
Purpose: Distraction osteogenesis(DO)is widely used in treating bone deformities and defects.However,inferior alveolar n......
Adenovirus-mediated interferon-γ gene therapy efficiently induced human pancreatic carcinoma Capan-2
Background: Pancreatic cancer survival continues to be amongst the shortest of all cancers, and new therapies are urgent......
Objective to construct a recombinant adenovirus vector that containing hVEGF165 (pAdxsi-EGFP-hVEGF165),and to observe th......
Conserved dopamine neurotrophic factor (CDNF) is atrophic factor for dopamine neurons.Intrastriatal injection of CDNF wa......
Duchenne muscular dystrophy (DMD) is a fatal disease caused by dystrophin deficiency.Dystrophy symptom is seen in the ca......
Objective The elongation factor Tu GTP binding domain containing 2(Eftud2)encodes a GTPase which is a component of the s......
In the past several years, gene therapy has received significant attention due to its potential application in the repla......
Aim:To identify the characteristics of recombinant adenovirus modified PBMC-derived dendritic cells and their resistance......
Adeno-associated virus (AAV) mediated gene transfer has been demonstrated to be an effective approach for treating Parki......
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Tetracycline-regulated HSV-1 vector delivery of the LacZ gene into dorsal root ganglion via the scia
The epidemiological studies of peripheral nerve injuries (PNIs) have shown that the incidence of PNIs may vary according......
hTERTC27,a 27 kDa C-terminal polypeptide,can induce telomere dysfunction and inhibit tumor cell proliferation.To study t......
